Poliomyelitis and eradication problems
نویسندگان
چکیده
Poliomyelitis je zĂĄvaĹžnĂĄ infekcia vyvolanĂĄ neurotropnĂ˝m vĂrusom. V minulosti ochoreli najmä deti do 5 rokov veku, v zaostalĂ˝ch oblastiach sa vyskytovali epidĂŠmie. NĂĄkaza prebiehala asymptomaticky alebo ako febrilnĂŠ chrĂpke podobnĂŠ ochorenie a asi u 1 % chorĂ˝ch manifestovala paralĂ˝zami konÄatĂn. UĹž viac 60 vo svete ploĹĄne oÄkujĂş inaktivovanou (IPV) vakcĂnou, ale imunogĂŠnou orĂĄlnou Ĺživou vakcĂnou (OPV), obe s antigĂŠnmi troch typov poliovĂrusu (1, 2, 3). bĂ˝valom Äeskoslovensku zaÄalo oÄkovaĹĽ uĹž r. 1957 od 1960 (OPV). Patrili sme medzi prvĂŠ krajiny, ktorĂŠ oÄkovali ktorĂ˝m podarilo ploĹĄnou vakcinĂĄciou OPV dĂ´kladnou surveillance pomerne rĂ˝chlo dosiahnuĹĽ eliminĂĄciu cirkulĂĄcie divĂ˝ch poliovĂrusov ochorenĂ, neskĂ´r eradikĂĄciu. 1988 vyhl ĂĄsila WHO celosvetovĂ˝ program eradikĂĄcie poliomyelitĂdy (Global Eradication Initiative), ktorĂŠho ciele naplnili na Americkom kontinente (r. 1994), zĂĄpadnom Pacifiku 2000) eurĂłpskom regiĂłne 2002). FinĂĄlna fĂĄza (The Polio Strategy 2022-2026) problematickĂĄ, predstavuje zastaviĹĽ prenos endemickĂ˝ch (typ Af ganistane Pakistane) aj cirkulujĂşce derivovanĂŠ poliovĂrusy (cVDPV 3), sprĂĄvajĂş divĂŠ mĂ´Ĺžu vyvolaĹĽ paralĂ˝zy. ProblĂŠmom sĂş epidĂŠmie cVDPV typu 2 Afrike Ăzii, ich zvlĂĄdnutie vyvinula novĂĄ geneticky stabilnejĹĄia novel (nOPV2) vakcĂna. sĂşÄasnosti zostĂĄva pre potreby eliminĂĄcie ochorenĂ vyvolanĂ˝ch poliovĂrusmi VDV1,3 bivakcĂna elim inĂĄciu infekciĂ typom oÄkovanie trivakcĂnou OPV, monovakcĂnou mOPV2 nOPV2 nĂĄslednou aspoĹ jednou dĂĄvkou IPV. krajinĂĄch bez vĂrusu vyĹžaduje prechod z NaÄalej potrebnĂĄ kvalitnĂĄ hlĂĄsenĂm laboratĂłrne potvrdenĂ˝ch akĂştnych chabĂ˝ch parĂŠz, izolĂĄciou vĂrusov pacientov odpadovĂ˝ch vĂ´d, sekvenĂĄciou vzoriek vakcinĂĄciou.
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ژورنال
عنوان ژورنال: Ceskoslovenska? pediatrie
سال: 2022
ISSN: ['0069-2328']
DOI: https://doi.org/10.55095/cspediatrie2022/058